New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens

  • Authors: Herath, H. M. T.Bandara; Jacob, Melissa; Wilson, A. Alpus; Abbas, Hamed K.; Nanayakkara, N.P. Dhammika Nanayakkara.
  • Publication Year: 2012
  • Publication Series: Scientific Journal (JRNL)
  • Source: Natural Product Research 26:1-7

Abstract

Ethyl acetate extracts of Armillaria tabescens (strain JNB-OZ344) showed significant fungistatic and bacteristatic activities against several major human pathogens including Candida albicans, Cryptococcus neoformans, Escherichia coli and Mycobacterium intracellulare. Chemical analysis of these extracts led to the isolation and identification of four new compounds, emestrin-F (1), emestrin-G (2), 6-O-(4-O-methyl--D-glucopyranosyl)-8-hydroxy-2,7-dimethyl-4H-benzopyran- 4-one (3) and cephalosporolide-J (4), along with five other previously known compounds, emestrin (5), cephalosporolide-E (6), decarestrictine-C2 (7), ergosterol and brassicasterol. Structural elucidation of all compounds was carried out by NMR and MS analyses. Antimicrobial assays revealed that compounds 1 and 5 were responsible for the observed growth inhibitory activities of the fungal extracts against the human pathogens tested.

  • Citation: Herath, H. M. T.Bandara; Jacob, Melissa; Wilson, A. Alpus; Abbas, Hamed K.; Nanayakkara, N.P. Dhammika Nanayakkara. 2012. New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens. Natural Product Research 26:1-7, iFirst ISSN 1478–6427 published online 09Nov2012. http://www.tandfonline.com/doi/abs/10.1080/14786419.2012.738206
  • Keywords: Armillaria tabescens; emestrin; chromone; cephalosporolide; antimicrobial activity
  • Posted Date: September 19, 2013
  • Modified Date: August 20, 2014
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